منابع مشابه
From Membrane to Cytoskeleton Enabling a Connection
by regulating all of these activities. In particular, families of proline-rich proteins, the WASP/SCAR and Ena/VASP families, play crucial roles in actin dynamics, and are Song Hu and Louis F. Reichardt* Department of Physiology Howard Hughes Medical Institute University of California believed to act, at least in part, by binding and thereby regulating Profilin’s activity (Figure 1). In additio...
متن کاملFrom Membrane to Cytoskeleton: Minireview Enabling a Connection
by regulating all of these activities. In particular, families of proline-rich proteins, the WASP/SCAR and Ena/VASP families, play crucial roles in actin dynamics, and are Song Hu and Louis F. Reichardt* Department of Physiology Howard Hughes Medical Institute University of California believed to act, at least in part, by binding and thereby regulating Profilin’s activity (Figure 1). In additio...
متن کاملSmall GTPases: Mechanisms Linking Membrane Traffic to Cytoskeleton During Neuritogenesis
During neurite extension, the protrusive activity of the neuronal growth cone is mediated by the coordination of membrane traffic, adhesion to the cell substrate, and reorganization of the cytoskeleton that includes the dynamic rearrangement of actin filaments at the peripheral region of the growth cone. The small GTPases of the Rho family are important regulators of the actin cytoskeleton (Hal...
متن کاملFrom plasma membrane to cytoskeleton: a novel function for semaphorin 6A.
Class III beta-tubulin (TUBB3) overexpression has been reported in ovary, lung, breast, and gastric cancer patients. Currently, no clinical drugs are available for a specific targeting of TUBB3, whereas the investigational drug IDN5390 specifically interacts with TUBB3. To gain insight into the pathways leading to TUBB3 up-regulation, we did a human genome microarray analysis in A2780 cells mad...
متن کاملA membrane cytoskeleton from Dictyostelium discoideum. III. Plasma membrane fragments bind predominantly to the sides of actin filaments
The binding between sonicated Dictyostelium discoideum plasma membrane fragments and F-actin on Sephacryl S-1000 beads was found to be competitively inhibited by myosin subfragment-1. This inhibition is MgATP-sensitive, exhibits a Ki of approximately 5 X 10(-8) M, and is reciprocal, since membranes inhibit the binding of 125I-heavy meromyosin to F-actin on beads. These experiments demonstrate t...
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ژورنال
عنوان ژورنال: Neuron
سال: 1999
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80696-0